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Xeloda (capecitabine) Indications

Xeloda, generic name capecitabine, is a chemotherapy drug used for the treatment of various types of cancer. Capecitabine is commonly used as an accessory treatment for colon cancer after surgical resection of the primary tumor and can be used as a single agent or in combination with other chemotherapy drugs for the treatment of metastatic colorectal or breast cancer.

Capecitabine belongs to the class of chemotherapy drugs known as antimetabolites. Antimetabolites interfere with the metabolism of cancer cells, which prevents cancer cells from dividing and multiplying, ultimately leading to cell death.

Xeloda (capecitabine) Uses and Dosage

Capecitabine is taken by mouth in the form of tablets that are swallowed whole with water. The tablets are taken twice daily (in the morning and evening), within 30 minutes after a meal, for 2 weeks followed by a 1-week rest period.

The specific treatment schedule may vary depending on the individual’s diagnosis, medical history, and overall health, in addition to other factors such as age, weight, and kidney function.

Follow the instructions provided by your healthcare professional carefully. Do not adjust the dose or schedule of capecitabine without consulting your doctor, as this can affect the efficacy and safety of the treatment.

In addition to taking the medication as prescribed, patients must attend all scheduled medical appointments and laboratory tests to monitor their response to treatment and assess for any potential side effects.

Xeloda (capecitabine) Side Effects

Common side effects of capecitabine are as follows:

• Nausea and vomiting
• Diarrhea
• Fatigue and weakness
• Loss of appetite
• Mouth sores
• Hair loss
• Changes in taste

Severe side effects of capecitabine that require immediate medical attention include:

• Severe or persistent vomiting or diarrhea
• Dehydration
• Fever, chills, or other signs of infection
• Chest pain or shortness of breath
• Severe skin rash or blistering
• Unusual bleeding or bruising
• Severe abdominal pain
• Irregular heartbeat
• Hand-foot syndrome (redness, swelling, and pain in the hands and feet)

Capecitabine has the potential to trigger allergic reactions in some individuals. Indications of an allergic reaction can include:

• Itching
• Hives
• Skin rash
• Swelling of the face, lips, tongue, or throat
• Difficulty breathing
• Chest pain or tightness

If any of these symptoms occur following use of capecitabine, then seek immediate medical assistance.

Xeloda (capecitabine) Cautions

Individuals with the following conditions should not use capecitabine:

• Severe kidney disease or require hemodialysis
• Liver disease
• Heart disease
• Low body weight
• Compromised immune function
• Elderly patients (over the age of 65 years of age)
• Dihydropyrimidine dehydrogenase (DPD) deficiency
• Pregnant or breastfeeding

Capecitabine can interact with certain medications, including:

• Phenobarbital or phenytoin
• Leucovorin
• Allopurinol
• Antacids
• Blood thinners (warfarin, aspirin)
• John’s wort

Capecitabine can suppress the immune system, which may increase the risk of infections, therefore, individuals should avoid exposure to infections and promptly report any of the following symptoms: fever, chills, or sore throat.

Taking capecitabine can harm a developing fetus and should not be used during pregnancy. Breastfeeding is not recommended while taking capecitabine as it can be excreted into breast milk and harm the baby.

Xeloda (capecitabine) Form and Strength

Xeloda is available in the following forms and strengths:

• Xeloda tablet
  • 150 mg
  • 500 mg
• Capecitabine tablet
  • 150 mg
  • 500 mg

FAQ

Does Xeloda prolong life?

Xeloda may help to extend a person’s life by slowing down the progression of cancer and preventing it from spreading to different parts of the body.

How long can a person take Xeloda?

Xeloda is commonly taken for two weeks, followed by a week off, before starting the next cycle. The number of treatment cycles can vary depending on the specific condition being treated and how well the person is responding to treatment.

Resources

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020896s037lbl.pdf
2. https://www.drugs.com/xeloda.html
3. https://www.webmd.com/drugs/2/drug-7906/xeloda-oral/details
4. https://www.rxlist.com/xeloda-drug.htm#description