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Vagifem Vaginal Tablet (estradiol) Indications

Vagifem, generic name estradiol, is a vaginal tablet prescribed for the treatment of atrophic vaginitis in menopausal women. It helps relieve vaginal symptoms, such as vaginal dryness, irritation, soreness, itching, pain during intercourse, and painful urination.

This medication is classified as an estrogen derivative. Vagifem is partly in control of the maintenance and development of the female reproductive system and secondary sexual characteristics. It also regulates the pituitary secretion of gonadotropins, follicle-stimulating hormone, and luteinizing hormone.

Vagifem Vaginal Tablet (estradiol) Uses and Dosage

Make sure to read the drug leaflet before using Vagifem vaginal tablets. Administer this medication exactly as instructed.

Vagifem vaginal tablets are prescribed as one tablet daily for the first two weeks and then one tablet two times a week thereafter. Insert the tablet on the same day each week. A dosing schedule will help to avoid missing a dose.

How to insert Vagifem vaginal tablets:

1. Remove the single applicator from the packaging.
2. Hold the applicator with one hand in a way that a finger can press the plunger.
3. Select the best position for the insertion of the tablet into the vagina.
4. Use the other hand to guide the applicator during insertion. Insert until half of the applicator is within the vagina or as far as it is comfortable.
5. Press the plunger fully to release the tablet inside the vagina.
6. Carefully remove and throw away the applicator.

Vagifem Vaginal Tablet (estradiol) Side Effects

Common side effects of using Vagifem are the following:

• Headache
• Dizziness
• Nausea
• Vomiting
• Bloating
• Stomach cramps
• Diarrhea
• Weight changes
• Acne
• Increased facial hair
• Vaginal itching or discharge

These adverse effects are expected, but if they get worse, you should consult your physician.

Serious Side Effects

The rare, yet severe, adverse effects of Vagifem include:

• Upper respiratory tract infection
• Unusual vaginal bleeding
• Breast lumps
• Increased or new vaginal irritation
• Unusual vaginal discharge/infection
• Severe abdominal pain
• Persistent nausea and vomiting
• Depression or other mental changes
• Increased thirst and urination
• Severe headache
• Unusual sweating
• Chest pain
• Weakness on one side of the body
• Sudden vision changes
• Trouble breathing
• Fainting
• Severe dizziness
• Pain or swelling in the legs

If any of the adverse effects above develop, then please report them immediately.

Allergic Reactions

Do not administer Vagifem if you have an allergy to estradiol or other ingredients that this product contains. Seek emergency medical help if the following signs of an allergic reaction develop:

• Itching
• Rashes
• Hives
• Swelling of the face and neck
• Severe dizziness
• Wheezing
• Trouble breathing

Vagifem Vaginal Tablet (estradiol) Cautions

Vagifem prescription vaginal tablets are contraindicated for women with or who have a history of:

• Problems in the uterus
• Vaginal bleeding of unknown cause
• Breast lumps
• Breast cancer
• Ovarian cancer
• Uterine cancer
• Stroke
• Blood clots
• Heart disease
• Liver disease, dysfunction, porphyria
• Kidney disease
• Mineral imbalance
• High cholesterol levels
• High blood pressure
• Diabetes
• Lupus
• Obesity
• Seizures
• Asthma
• Hypothyroidism and hypoparathyroidism
• Gallbladder disease
• Dementia, depression, or other mental or mood changes

Do not smoke or use tobacco or e-cigarettes while using Vagifem. Nicotine can increase the risk of blood clot formation, stroke, hypertension, and heart attack.

Vagifem is not indicated for women who are pregnant or lactating.

Vagifem Vaginal Tablet (estradiol) Form and Strength

Vagifem is available in the following strengths:

• Vagifem, vaginal tablets
  • 10 mcg
  • 25 mcg

FAQ

How quickly does Vagifem work?

Vagifem may start to work as soon as the vaginal tablet has been inserted. However, the full benefits may be achieved after 8-12 weeks of use.

Does Vagifem cause weight gain?

Vagifem may cause swelling, fluid retention, and weight gain. However, it can also cause weight loss because of the appetite changes that this medication may cause.

When is the best time to use Vagifem?

You may insert the Vagifem vaginal tablets at any time of the day, yet it is best to use it at the same time on the days when insertion is scheduled.

Does Vagifem cause odor?

Vagifem should relieve vaginal symptoms and should not cause any unusual or foul odor. If an unusual odor or vaginal discharge occurs, please contact your doctor.

Resources

https://www.webmd.com/drugs/2/drug-18858/vagifem-vaginal/details

https://www.vagifem.com/treatment/step1

https://www.rxlist.com/vagifem-side-effects-drug-center.htm

https://www.medbroadcast.com/drug/getdrug/vagifem

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020908s013lbl.pdf